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Academic Article
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Activity of one of two engineered heterodimers of AhpF, the NADH:peroxiredoxin oxidoreductase from Salmonella typhimurium, reveals intrasubunit electron transfer between domains.
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Academic Article
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Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase.
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Academic Article
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Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase.
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Academic Article
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Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines.
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Academic Article
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Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.
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Academic Article
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Protein sulfenic acids in redox signaling.
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Academic Article
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Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin.
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Academic Article
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Synthesis of chemical probes to map sulfenic acid modifications on proteins.
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Academic Article
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Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase.
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Academic Article
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Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.
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Academic Article
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Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins.
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Academic Article
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Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells.
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Academic Article
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Formation and functions of protein sulfenic acids.
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Academic Article
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Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
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Academic Article
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Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis.
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Academic Article
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Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family.
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Academic Article
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Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers.
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Academic Article
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Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses.
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Academic Article
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AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.
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Academic Article
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An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum.
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Academic Article
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Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.
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Academic Article
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An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro.
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Academic Article
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Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61.
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Academic Article
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Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme.
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Academic Article
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Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases.
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Academic Article
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Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.
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Academic Article
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Novel organic hydroperoxide-sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress.
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Academic Article
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Cysteine reactivity and thiol-disulfide interchange pathways in AhpF and AhpC of the bacterial alkyl hydroperoxide reductase system.
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Academic Article
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The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
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Academic Article
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Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins.
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Academic Article
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Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity.
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Academic Article
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Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid.
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Academic Article
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Cysteine pK(a) values for the bacterial peroxiredoxin AhpC.
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Academic Article
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Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase.
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Academic Article
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Structural changes common to catalysis in the Tpx peroxiredoxin subfamily.
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Academic Article
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Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.
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Academic Article
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Engineering of fluorescent reporters into redox domains to monitor electron transfers.
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Academic Article
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Measurement of protein sulfenic acid content.
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Academic Article
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PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family.
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Academic Article
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Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species.
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Academic Article
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Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.
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Academic Article
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Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis.
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Academic Article
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Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin.
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Academic Article
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A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of ß-ketoesters as cleavable probes.
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Academic Article
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A new family of membrane electron transporters and its substrates, including a new cell envelope peroxiredoxin, reveal a broadened reductive capacity of the oxidative bacterial cell envelope.
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Academic Article
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The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation.
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Academic Article
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Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes.
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Academic Article
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Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry.
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Academic Article
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Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity.
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Academic Article
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AhpF and other NADH:peroxiredoxin oxidoreductases, homologues of low Mr thioredoxin reductase.
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Academic Article
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Essential thioredoxin-dependent peroxiredoxin system from Helicobacter pylori: genetic and kinetic characterization.
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Concept
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MAP Kinase Signaling System
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Concept
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Biological Transport
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Concept
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Peroxynitrous Acid
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Concept
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Amino Acids
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Concept
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Amino Acid Substitution
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Concept
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Receptors, Lysophosphatidic Acid
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Concept
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Database Management Systems
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Concept
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Amino Acid Sequence
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Concept
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Ascorbic Acid
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Concept
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Sulfenic Acids
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Concept
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Vesicular Transport Proteins
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Concept
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Sulfinic Acids
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Concept
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Protein Transport
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Concept
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Yeasts
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Concept
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Electron Transport
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Concept
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Sequence Homology, Amino Acid
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Concept
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Dithionitrobenzoic Acid
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Concept
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Electron Transport Chain Complex Proteins
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Concept
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Amino Acid Motifs
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Academic Article
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Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.
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Academic Article
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The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.
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Academic Article
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Chemical approaches to detect and analyze protein sulfenic acids.
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Academic Article
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Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling.
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Academic Article
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Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.
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Academic Article
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Strained cycloalkynes as new protein sulfenic acid traps.
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Academic Article
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Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function.
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Academic Article
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Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.
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Academic Article
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X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.
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Academic Article
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Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics.
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Academic Article
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Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form.
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Academic Article
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Peroxiredoxin Catalysis at Atomic Resolution.
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Academic Article
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An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins.
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Grant
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Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
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Grant
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New Reagents for Tracking Protein Oxidation in Cells by MS and Imaging Methods
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Grant
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2012 Thiol-based Redox Regulation &Signaling GRC and GRS
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Grant
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Proteomic Profiling of Cancer-Related Redox Signaling Pathways
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Grant
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2010 Thiol-based Redox Regulation &Signaling Gordon Research Conference
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Grant
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Profiling of Redox-Sensitive Signaling Proteins
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Grant
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Structural and Computational Biophysics Training Program
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Grant
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Mechanisms and Regulation of Peroxiredoxins
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Academic Article
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Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
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Academic Article
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The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.
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Academic Article
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Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.
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Grant
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Redox Biology and Medicine Training Program
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Academic Article
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Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.
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Academic Article
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Mitochondria-targeted Probes for Imaging Protein Sulfenylation.
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Academic Article
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H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes.
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Academic Article
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Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function.
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Academic Article
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Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193.
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Grant
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Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction Pathways
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Academic Article
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Identification of sulfenylation patterns in trophozoite stage Plasmodium falciparum using a non-dimedone based probe.
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Academic Article
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Bioinformatic Analyses of Peroxiredoxins and RF-Prx: A Random Forest-Based Predictor and Classifier for Prxs.
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Academic Article
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Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug.
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Academic Article
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Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.
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Academic Article
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Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis.
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